Are you a mouse or a keyboard person?  If you like to utilize keyboard shortcuts, here are a few QuickBooks keyboard shortcuts that will speed up some tasks and make your QuickBooks time more efficient...  
Navigating Dates
  • Move dates forward or backwards one day at a time - Use the Plus (+) or Minus (-) keys.
  • Go straight to the beginning or end of the week - Use the W key for the first of the week and the K key for the last day of the week. Remember WeeK to recall the letters to use.
  • Go straight to the beginning or end of the month - Use the M key for the first of the week and the H key for the last day of the week. Remember MontH to recall the letters to use.
  • Go straight to the beginning or end of the year - Use the Y key for the first of the week and the R key for the last day of the week. Remember YeaR to recall the letters to use.
  • Go straight to Today's Date - Use the T key.
 
Performing Calculations in Amount Fields
Any amount field within QuickBooks is armed with a complete calculator.  To enable the function, just start typing in the calculation you want to perform within the field.  Addition uses the plus key (+), subtraction uses the minus key (-), multiplication uses the star key (*), and division uses the slash key (/). For instance, if you want to add up multiple numbers, just enter the first number, then push the plus (+) key and continue entering the subsequent numbers followed by the plus (+) key after each number.  Once you have entered all numbers, push the enter key to see the total. If you'd like to multiply a number by another number, just enter the first number, then use the star key (*) and then enter the next number followed by the enter key to get your result.  
Working with transactions
  • Open the Write Checks Window - Use Ctrl-W.
  • Enter a New Transaction - Use Ctrl-N when in the Invoice, Bill, or other transaction forms.
  • Delete Line from Transaction - Use Ctrl+Del.
  • Insert Line into Transaction - Use Ctrl+Ins.
  • Delete Entire Transaction - Use Ctrl-D
  • Close active window - Use the Esc key.
  • Find a transaction - Use Ctrl-F
  • View History or Linked Transactions - Use Ctrl-H
 
Other Helpful Shortcuts
  • Open Chart of Accounts - Use Ctrl-A
  • Print - Ctrl-P 
  • Open QuickBooks without opening a company file - Hold Ctrl while opening QuickBooks.
  • Supress all windows when Open a Company File - Hold Alt while opening QuickBooks company file.
  • Open Help - Use F1 key.
  • Show technical information about your company file - USe the F2 key while in the company file.
  • Undo Changes made - Ctrl-Z.